NVP-LAQ824; Origin and activity
LAQ824 is highly effective histone deacetylase inhibitor and is in a phase of completing Phase I clinical trials in hematologic and solid malignancies. The inhibitor shows a great antileukemic effect when administrated in small nanomolar ranges and this is its high effectiveness that has made it a strong candidate for clinical developments. [2]

If compared to HDACI butyrate, NVP_LAQ824 is 50,000 times more potent both in activity and in inhibition ability without imparting toxicity to peripheral blood and normal marrow. Recent research work has revealed a great potential of LAQ824 inhibitor in treating leukemia and some other malignancies. [3,4]

Research Carried on NVP-LAQ824:
Structurally, NVP-LAQ824 is a novel derivative of hydroxamic acid (designated as prototype), which has an ability to inhibit HDAC at a nanomolar ranges (0.15_M or even less). The inhibitor has a potential to trigger colon cancer cell line inhibition at medium inhibitory concentration of less than 1_M. Chemically, the inhibitor LAQ824 is derived from 4-aminomethylcinnamic hydroxamic acid and is represented by chemical formula C22H25O3 (akt inhibitors)

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NVP-LAQ824 inhibitor has been tested for its effectiveness in MM10 and the results showed that the inhibitor was highly effective in this range. The inhibitor has been explored to gauge its antitumor activity and the mechanism of action of this potent HDAC inhibitor in MM cells. The studies provided an insight to know the preclinical rationale clinical protocols making use of this novel NVP-LAQ824 inhibitor.
Activity of LAQ824 against E?-myc lymphoma :
Extensive research has been carried out to determine the ability of NVP-LAQ824 to kill the  E?-myc cells in vivo and the results revealed that  HDAC inhibitor induces fast and extensive apoptosis in E?-myc lymphoma cells within MM cell lines and smaller animals. The activity of LAQ824 inhibitor in tumors is devoid of a functional p53 pathway which shows that therapeutic efficiency of LAQ824 is independent of P53 pathways. In addition to this, the therapeutic activity of LAQ824 is also independent of apoptosome formation.
LAQ824 is characterized to induce morphologic changes related to autophagy. LAQ824 originates an increase in the levels of LC3-II and a simultaneous decrease in the amount of LC3-I.
Conclusion:
In conclusion, LAQ824 has the ability to induce apoptosis of E?-myc lymphomas utilizing the intrinsic apoptotic pathway without any evidence for a noteworthy role of the death receptor pathway. Inducing the lymphoma cell death in vitro and in vivo by LAQ824 directly relates to the therapeutic efficiency of these HDAC inhibitors. [5]
References:
1) Catley L et al. NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood. 2003 Oct 1;102(7):2615-22.)
 2) Urnov FD, Yee J, Sachs L, et al. Targeting of NCoR and histone deacetylase 3 by the oncoprotein v-erbA yields a chromatin infrastructure-dependent transcriptional repression pathway. Embo J. 2000;19:4074-4090.
3) Blagosklonny MV, Robey R, Sackett D, et al. Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest,and cytotoxicity. Mol Cancer Ther. 2002;1:
937-941.
4)  Lund AH, van Lohuizen M. Epigenetics and cancer. Genes Dev 2004;18:2315-2335.
5) Catley L, Weisberg E, Tai YT, et al. NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood 2003;102:2615-2622.
Buy  inhibitors for research work. Well known by scientists and researchers worldwide for PTC124, rad001, ABT-737 and other inhibitors.If you would like to get more specific information about some life research product like Fingolimod , Lenalidomide ,Revlimid etc than you can check the link list bottom of this page or visit directly to http://www.selleckchem.com
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I. Causes of enlarged prostate and prostate cancer
1. Genetics
Genetics may also play a role in enlarged prostate since study shows that prostate cancer and enlarged prostates can be inherited from generation to generation.

2. Hormone imbalance
The outward appearance of a typical middle-aged person shows increased abdominal fat and shrinkage of muscle mass, which is the main factor causing hormone imbalance. Hormone imbalance is also caused by depression, stress, and anxiety that are the most common psychological complications of hormone imbalance.

3. Cell-growth factor
For whatever reason, some people have implicated in enlarged prostate that is a growth factor.

4. Mineral deficiency
Our prostate contains high amounts of zinc to function normally. Zinc deficiency causes the prostate to enlarge. This may be due to aging or uncontrolled diet with excessive alcohol drinking.

5. Obesity
Study shows that uncontrolled diet that is high in saturated and trans fats are the main cause of hormone imbalance that results in prostate enlargement. Researchers suggest that excess calorie consumption could somehow directly stimulate prostate enlargement because the excess body fat that accumulates causes an imbalance of hormone levels.

6. Testosterone
Testosterone deficiency may be caused by high amounts of the by-product prolactin of testosterone of men in the body that stimulates even higher productions of the enzyme 5-alpha reductase resulting in a high amount of the conversion of testosterone to gihydro-testosterones DHT thus triggering prostate enlargement. Excess estrogen seems to be the culprit in prostate enlargement that leads to the pathology and favors the development of prostate cancer.

III. Symptoms
1. Nocturia.
Nocturia is defined as being awakened at night one or more times in order to pass urine. It becomes more common as the person becomes older. This common pattern seen among people with this condition is an increased number of times of waking up every night to urinate for the rest of their life.

Nocturnal Polyuria is an important cause of nocturia in which there is an overproduction of urine at night. It is defined to have nighttime urine volume that is greater than 20-30% of the total 24 hour urine volume. Nocturia occurs more commonly among older people. It also occurs in women and men differently. Women generally experience nocturia as a result from childbirth, menopause, and pelvic organ prolapse. Nocturia in men can be directly attributed to benign prostatic hyperplasia (BPH), also known as enlarged prostate.

2. Dysuria.
Dysuria is a complication associated with genitourinary infections usually resulting in painful urination because the infection has made its way into the urinary tract, resulting in a urinary tract infection. Dysuria in men is usually indicative of a complication of the prostate, commonly referred to as prostatic hyperplasia caused by hormonal imbalances associated with estrogen production.

3. Asymptomatic
As we know the prostate gland becomes enlarged as a man ages. Asymptomatic inflammatory prostatitis may be diagnosed when infection-fighting cells are present causing common symptoms of prostatitis such as difficulty with urination, fever, and lower back and pelvic pain.

4. Epididymitis
Epididymitis is an inflammation of the epididymis that connects the testicle with the vas deferens. Epididymitis is usually caused by infection of the urethra or the bladder. Epididymitis may begin with a low grade fever and chills with a heavy sensation in the testicle which becomes increasingly sensitive to pressure or traction.

III. Prevention and treatment
A. With Foods
1. Tomato
Tomatoes contain a high amount of lycopene that can help to protect the prostate and keep it healthy, but raw tomato is hard to digest. Be sure to take tomato with dark green leafy vegetables for helping the absorption of lycopene.

2. Soy bean and legume
Soybeans and legumes contains isoflavones and is a unique source of phytochemicals It directly inhibits the growth of different types of cancer cells and protects the prostate from being enlarged. Study shows that isoflavones were found to markedly inhibit prostate tumors in mice implanted with prostate cancer cells. Try adding soy or rice milk to your morning cereal or oatmeal.

2. Grapefruit
Grapefruits contain high amounts of vitamin C, minerals, bioflavonnoids and other plant chemicals that help to prevent enlarged prostate, prostate cancer and other forms of cancer and heart diseases.

3. Papaya
Papayas are rich in antioxidants, vitamin E, vitamin C, vitamin A, carotenoids and flavonoids that have cardio protective and anti-cancer effects. Eating papayas help to promote lung health and prevents the prostate from becoming enlarged and prevents prostate cancer.

4. Bean
Beans are rich in inositol pentakisphosphate. Beans are high in fiber, which helps the body rid itself of excess testosterone that reduces the conversion of testosterone to gihydro-testosterones DHT thus triggering prostate enlargement and other problems.

5. Green tea
Green tea contains the antioxidant phytochemicals called polyphenols that attack growth factors and proteins, interrupting processes that increase the size of tumors, thus preventing them from spreading to other parts of the body. Green tea also help to prevent the development of benign prostate hyperplasia such as enlarged prostate and prostate cancer.

6. Broccoli
Broccoli and other cruciferous vegetables, including kale and cauliflower, are rich in sulphoraphane, a cancer-fighting phytochemical that helps rid the body of excess testosterone and reduces the risk of benign protatic hyperplasia and prostate cancer.

7. Cold water fish
Cold water fish contains high amounts of Omega-3 fatty acids. Study shows that omega-3 fatty acids inhibit carcinogenesis that helps significantly lower levels of omega-3 polyunsaturated fatty acids in men with benign prostate hyperplasia and prostate cancer.

B. With Supplements
1. Bee pollen
Bee pollen is an antioxidant containing high amounts of flavonoids, zinc and many other elements needed by our bodies. It has an astounding record at reversing prostate cancer and other prostate problems such as enlarged prostate.

2. Prostate glandulars
Animal prostates contain high amounts of zinc that nourishes the human prostate.

3. Alanine
Since alanine is present in prostate fluid, it plays an important role in prostate health. This has been confirmed in some studies that Alanine helps in preventing enlarged prostate and helps in strengthening the immune system.

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4. Glutamics acid
The fluid produced by the prostate gland also contains high amounts of glutamic acid, and may play a role in the normal function of the prostate. High dosages of glutamic acid may cause headaches and neurological problems and people with kidney or liver disease should not consume high intakes of amino acids without first consulting with your doctor.

5. Glycine
Glycine is also found in fairly large amounts in the prostate fluid and may for this reason be important in prostate health. It is required to build proteins in the body and synthesis of nucleic acids, the construction of RNA as well as DNA, bile acids and other amino acids in the body. Study shows that glycine, taken withalanine and glutamic acid help to reduced the amount of swelling in the prostate tissue.

6. Lycopene
The substance found in tomatoes, fruits and vegetables can prevent and slow down prostate inflammation and prostate cancer. Study shows that lycopene helps to decrease in DNA the damage to prostate cells. Lycopene also protects against LDL cholesterol oxidation.

C. With Herbs
1. Saw palmetto
Saw palmetto is the number one choice when it comes to prostate health. Recent study of American Society for Cell Biology shows that saw palmetto inhibited prostate cancer cell growth in the test tube. It has been used for a long time as an herb to treat an enlarged prostate gland in men. It may also be used to treat prostate cancer. This herbal remedy has no significant side effects and only rarely causes mild stomach upset or diarrhea.

2. American Ginseng
The roots, has been used for centuries in Asian medicine as an aphrodisiac, a tonic for well being and a curative. American Ginseng is helpful in treating prostate problems due to low testosterone and androgen levels. It also inhibits cancer cells proliferation in a variety of cancer such as lung cancer, colon cancer and prostate cancer.

3. Corn silk
Corn silk contains certain therapeutic properties that help to relieve the inflammation of the prostate. Corn silk are also popular as an alternative to standard Western allopathic medicine for treating bed-wetting and obesity.

4. Pumpkin seed extract
Pumpkin seeds contain high amounts of zinc and fatty acids which is necessary for the prostate’s health. Pumpkin seed extract helps to tone the bladder muscles, relax the sphincter mechanism and recongest the prostate.

5. Pygeum Africanum
Pygeum Africanum is rich in phytosterols, the substances that inhibit the biosynthesis of prostaglandins, which is the process responsible for prostate inflammation. Phytosterols also help to reduce the size of the prostate, promote normal urination and reduce cholesterol deposits in the prostate that can occur with BPH.

6.Essiac
Essiac is useful to regulate prostate gland function, stimulates gland activities, promote circulation of blood, relieves pain and inflammation and may permit increase sexual activities. Study shows that essiac possesses potent antioxidant and DNA-protective activity, properties that are common to natural anti-cancer agents.

7. Uva ursi
Uva ursi is an evergreen perennial shrub. It has been used since the year 150AD by various civilizations to treat urinary tract infections, kidney problems, Prostate, and bladder dysfunction.

8. Soy isoflavones
Study shows that an increased soy intake is related to a reduced risk of prostate cancer. Vitro tests showed that soy isoflavone inhibits growth of both androgen-sensitive and androgen-independent prostate cancer cells.

D. With Chinese Herbs
1. Saw palmetto
Saw palmetto has been used for over a century in traditional Chinese medicine in treating pain in the lower back, inflammation and enlargement by inhibiting dihydrotestosterone, thereby reducing its stimulation for cancerous cell multiplication.

2. Patrinia (Bai jiang cao)
Patrinia helps the body get rid of prostate inflammation and damp heat that exists in the body. In Chinese medicine damp heat in the prostate could be caused by bacteria infection, drugs and other conditions such as a habit of eating hot, spicy or greasy foods.

3. Lu lu tong (liquid amber)
Lu lu tong has the ability to improve qi and blood circulation . It also helps to reduce the abdominal, back and knee pain caused by damp heat as well as difficult urination because of bladder or prostate inflammation.

4. He shou wu
He shou wu contains several derivatives of tetrahydroxystilbene. These antioxidants and anti-inflammatory compounds may act as an estrogen, reducing levels of circulating male hormones such as DHT that fuel the growth of prostate cancer.

5. Niu xi (Achyranthes)
Niu xi contains triterpenoid saponins and sitosterol that possesses anti-inflammatory effects in both enlarged prostate and prostate cancer inflammation. It also helps to nourish the kidney liver and reduce symptoms of damp heat and difficult urination as well as stiffness and pain of lower back.

6. Gui Zhi (tokoro)
Gui Zhi is used for urinary tract disorder that pertains to ying qi levels which is the main cause of prostate inflammation. It also is used as a tonic and blood purifier.

7. Astragalus root
Astragalus root is a sprawling perennial legume. The Chinese medicine uses the dried sliced or powdered root of the plant to enhance immune function by increasing the activity of certain white blood cells, which increases the production of antibodies. It also helps to increase the body’s resistance to infections, to heal the allergies, and to raise and renew the vitality.

8. Che Qian zi (plantago seed)
It is mainly used for stone strangury caused by lower burner damp-heat, such as the symptoms of aching pain in the lumbus and abdomen, poor urination or with hematuria, and urinary tract stones.

9. Vaccaria seed
It is used to reduce pain and stiffness in the lower back, drain excessive damp heat, invigorate blood and treat difficult urination.

E. With Vitamins & Minerals
As we mentioned in previous articles, We know that starting at age 40, the levels of by-product prolactin of testosterone of men increases, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT triggering prostate enlargement and other problems. Besides aging there are many other causes of enlarged prostate and some of them might result in prostate cancer. Beside foods nutrition and herbs, vitamins and minerals also play an important role in preventing and treating prostate enlarged as well as prostate cancer.

1. Zinc
Zinc is necessary for male sexual and prostate health. Zinc inhibits the uptake of testosterone into prolactin. The prostate gland contains a higher concentration of zinc than any other organ in the body, therefore zinc deficiency is the major cause of enlarged prostate as well as an early indication of prostate cancer.

2. Selenium
Selenium contains an antioxidant enzyme that helps to enhance immune function, stop early cancer cells in their development and control cell damage that may lead to cancer. Foods that contain high levels of selenium are bran, broccoli, eggs, mushroom, and basil nut.

3. Vitamin C
As we know Vitamin C, a water-soluble vitamin, is commonly known as an antioxidant. Some studies show that increased levels of vitamin C reduce the risk for prostate cancer as well as prostate inflammation and enlarged prostate.

4. Vitamin D
Vitamin D is found in foods and is also produced by the body and activated after exposure to ultraviolet light from the sun. Studies show that activated vitamin D may be broken down in the prostate, where it may plays an important role in preventing enlarged prostate and prostate cancer. Vitamin D deficiency may increase the risk of prostate cancer.

5. Vitamin E
Vitamin E plays an important role in preventing prostate cancer because it interferes with prostate specific antigen (PSA) and androgen receptor proteins that play a central role in the development of the disease.

F. With Homeopathic Remedies
1.Chimaphilia
Chimpaphilia acts principally on kidneys, and genito-urinary tract; affects also lymphatic and mesenteric glands. It helps in treating urge to urinate with burn pain, strain to urinate and prostate enlargement and irritation.

2.Conium maculatum
Conium maculatum is an excellent remedy for old age people. It helps to improve prostate enlargement, difficult urination, weakened urine flow and soften the prostate and enhance sexuality.

3. Hepar sulphuris calcareum
Hepar sulphuris calcareum is a mixture powder of oyster shells and pure flower of sulfur. You can purchase in mixture in a health food store and follow the instructions to make your own. Hepar sulphuris calcareum has proven record in treating dribbling urine and poor flow.

4. Sabal serrulata
Sabal serrulata is homeopathic to irritability of the genito-urinary organs. It is helpful in treating difficult urination caused by enlarged prostate, constant desire to urinate, as well as sexual inability.

5. Staphysagria
Staphysagria is helpful in treating diseases of the genito-urinary tract such as the urge to urinate, inability to urinate fully and feeling of bladder not being empty.

6. Thuja
The main action of thuja is on the genito-urinary organs. It is helpful in treating enlarged prostate, sudden desire to urinate and split urinary stream.

G. With Common Sense Approaches
1. Reduce fat and cholesterol intake, especially saturated fats.
Study shows that if you eat more than 5 servings of red meat every week you could increase the risk of enlarged prostate and prostate cancer by 80%. By eating less of red meat and replacing them with cold water fish, you are ensured yourselves to get enough omega fatty acid that helps to improve your prostate health, reduce cholesterol levels, lower the risk of enlarged prostate as well as prostate cancer.

2. Eat foods containing more zinc (nuts- especially walnuts, pumpkin, seeds, safflower seeds and oysters).
Zinc is an essential mineral for prostate health. It helps to reduce the size of the prostate and relieve symptoms of enlarged prostate. Foods containing zinc also contain cucurbitacines, chemicals that stop testosterone from changing to stronger forms of testosterone which encourages too many prostate cells to grow. Foods that contain cucurbitacines are nuts, walnuts, pumpkin seed, and oyster.

3. Guard your prostate with green tea
Green tea contains catechins, a chemical that helps our immune system to track down tumor cells before they can do any harm to the prostate cells. Green tea may be one reason that Asian people have far fewer cases of prostate cancer than North Americans.

4. Remove all chemicals and pesticides from diet (eat organic food).
Chemicals and pesticides in the processing food is toxic to our body. Intaking high doses of these poisonous chemicals will danger our immune system as well as cause inflammation of the body including the prostate.

5. Increase consumption of plants high in the sulphurophanes
Study shows that you could reduce the risk of prostate cancer and prostate enlargement by 45% if you eat 24 or more servings of vegetables that contain high amounts of sulphurophanes such as broccoli, cauliflower, brussel sprouts, and cabbage.

H. Activities That Help to Maintain a Healthy Prostate
1. Moderate exercise (like walking)
We know that one half to three-quarters of men older than 75 will have some cancerous changes in their prostate glands. People doing moderate exercise like walking for 2 to 3 hours per week had a 25 percent less risk of developing prostate problems than those who did not. Just 20-30 minutes walking a day would help to increase circulation of blood to the body as a side benefit for better sexual function and prostate health.

2. Sitz baths
It is one of the earliest prostate treatments and the most effective remedies for prostate pain. This special bath brings a great flow of blood to a specific area of the body while the regular hot bath is pleasant and generally increases circulation throughout your body.

3. Yoga
Yoga is really helpful to the prostate. It also helps tone the deep pelvic muscles there by promoting circulation. Yoga promotes flexibility, circulation, and stimulates the liver meridian. In general yoga helps a person to be more aware of his pelvic area in terms of his muscular control.

4. Kegal exercise
Kegal exercise when performed while in virasana, bhekasana or frog pose also promotes good prostate health and overall benefit to the urogenital tract.

5. Spinal and pelvic massage
Spinal and pelvis massage helps to
a) Increase blood supply to the prostate and the pelvic area.
b) Increase lymphatic flow to the prostate and the pelvic area.
c) Reduces inflammatory conditions.

6. Joyful sex life
Sex helps increase movement of the pelvic muscles and the blood circulation to all organs of your body. As fresh blood supply arrives your cells, organs and muscles are saturated with fresh oxygen and hormones, and as the used blood is removed, you also remove waste products and toxins from your body, thus reducing the risk of inflammation of the prostate.

You can see there are many different methods that help to maintain a healthy prostate. I hope this information will help. if you need more information. please visit my home page at:
Kyle J. Norton
http://medicaladvisorjournals.blogspot.com/
http://prostatehealth09.blogspot.com/
All rights reserved. Any reproducing of this article must have all the links intact.
I have been studying natural remedies for disease prevention for over 20 years and working as a financial consultant since 1990
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1. Breast cancer
In a study of `Curcumin decreases survival of Hep3B liver and MCF-7 breast cancer cells: the role of HIF.`by Ströfer M, Jelkmann W, Depping R. (Source from Department of Physiology, Center for Structural and Cell Biology in Medicine, University of Luebeck, Luebeck, Germany. troefer@physio.uni-luebeck.de) posted in US National Library of Medicine National Institutes of Health, researchers found that effects of curcumin on cell growth and survival factor expression suggest its potential benefit in the treatment of cancer without a direct radiosensitizing influence of curcumin on these cells.

2. Cancers and Alzheimer’s disease and Anti-inflammatory agent
a. Cancers
According to the study of `Induction of apoptosis by curcumin and its implications for cancer therapy.` by Karunagaran D, Rashmi R, Kumar TR. (Cancer Biology Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala 695 014, India.dkarunagaran@hotmail.com), posted in US National Library of Medicine National Institutes of Health, reseachers found that this review describes the mechanisms of curcumin-induced apoptosis currently known, and suggests several potential strategies that include down-regulation of antiapoptotic proteins by antisense oligonucleotides, use of proapoptotic peptides and combination therapy, and other novel approaches against chemoresistant tumors. Several factors including pharmacological safety, scope for improvement of structure and function of curcumin and its ability to attack multiple targets are in favor of curcumin being developed as a drug for prevention and therapy of various cancers.

  In an article of `Don’t Go Easy on Turmeric: It Prevents and Cures Cancer` by By VIJI SUNDARAM, India-West Staff Reporter(WEST PUBLICATIONS(Copyright India-West, July 15, 2005, www.indiawest.com), receptor wrote that Dr. Bharat Aggarwal, who headed the 12-member team of researchers at UT’s M.D. Anderson Cancer Center, told India-West in a telephone interview earlier this week that his clinical research has made available not only “the master switch to turn off cancer, but also a cure for it. It was already known that curcumin can prevent cancer,” Aggarwal said. “Now it can also be used to cure cancer.” And, he added: “We are providing evidence that curcumin can work on at least one dozen cancers.” Because of turmeric’s extensive use in foods in India and Pakistan, the incidence of cancer, especially breast, colon, prostate and lung, is a lot less in those countries, Aggarwal said. And because south Indians use turmeric more widely than north Indians, “the prevalence of cancer is less among them than among north Indians,” he said.

2. Alzheimer’s disease
According to Aggarwal, the team determined that curcumin is more effective in inhibiting formation of the protein fragments than many other drugs being tested to treat Alzheimer’s. The prevalence of the disease among older adults in India is 4.4 times less than in the U.S., suggesting that many Indians might be benefiting from having turmeric as a dietary staple.
In other study of `NSAID and antioxidant prevention of Alzheimer’s disease: lessons from in vitro and animal models.`by Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA. (Source from Greater Los Angeles Healthcare System, Veterans Administration Medical Center, North Hills, CA 91343, USA. gmcole@ucla.edu) posted in US National Library of Medicine National Institutes of Health, reseachers found that the unconventional NSAID/antioxidant curcumin was effective, lowering oxidative damage, cognitive deficits, synaptic marker loss, and amyloid deposition. Curcumin proved to be immunomodulatory, simultaneously inhibiting cytokine and microglial activation indices related to neurotoxicity, but increasing an index of phagocytosis. Curcumin directly targeted Abeta and was also effective in other models, warranting further preclinical and clinical exploration.

3. Anti-inflammatory agent
According to the study of evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. by Satoskar RR, Shah SJ, Shenoy SG., poated in US National Library of Medicine National Institutes of Health, researchers wrote that In this model of postoperative inflammation, the anti-inflammatory activity of curcumin (diferuloyl methane) was investigated in comparison with phenylbutazone and placebo. Phenylbutazone and curcumin produced a better anti-inflammatory response than placebo.

4. Antioxidants
In a study of `Protective Role of Curcumin Against Oxidative Stress,Immunosuppressive and Cytotoxic Effects of Lead Exposure` by Mahmoud El-sherbiny, Azza Araffa, Mona Mantawy and Hany M. Hassan (Therapeutic Chemistry Department, National Research Centre – Dokki, Giza, Egypt. Immunology Department, Animal Reproduction Research Institute (ARRI), Giza, Egypt), posted in World Applied Sciences Journal 12 (10): 1832-1838, 2011, researchers found that
ground, curcumin’s benefits on tumorigenesis are thought to be mediated by its antiinflammatory activity; however, these effects have not been well characterized in a mouse model of colon cancer. Briefly, curcumin is efficacious for chronic nonbacterial prostatitis in rats and the action mechanism may be associated with its decreasing effect on the proinflammatory cytokines IL-8 and TNF-alpha in the blood and tissues. Curcumin has protective effect on DNA of pulmonary cells. There was direct evidence for an involvement of curcumin in reducing arsenic and lead induced oxidative stress in Swiss albino mice by virtue of its antioxidant potential and trapping of free radicals. The current investigation concluded that curcumin has protective role against cytotoxic, immunosuppressive , oxidative and immunosuppressive profile that perform due to lead acetate exposure.

5. Amyloidosis
In a study of `Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.`by Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. (Source from Department of Medicine, UCLA, Los Angeles, CA 90095, USA.) posted in US National Library of Medicine National Institutes of Health, researchers found that curcumin labeled plaques and reduced amyloid levels and plaque burden. Hence, curcumin directly binds small beta-amyloid species to block aggregation and fibril formation in vitro and in vivo. These data suggest that low dose curcumin effectively disaggregates Abeta as well as prevents fibril and oligomer formation, supporting the rationale for curcumin use in clinical trials preventing or treating AD.

6. Chronic anterior uveitis
In a study of `Efficacy of curcumin in the management of chronic anterior uveitis.`by Lal B, Kapoor AK, Asthana OP, Agrawal PK, Prasad R, Kumar P, Srimal RC. (Source from Department of Ophthalmology, K.G. Medical College, Lucknow, India.) posted in US National Library of Medicine National Institutes of Health, researchers found that the efficacy of curcumin and recurrences following treatment are comparable to corticosteroid therapy which is presently the only available standard treatment for this disease. The lack of side effects with curcumin is its greatest advantage compared with corticosteroids. A double blind multi-centric clinical trial with this drug in CAU is highly desirable to further validate the results of the present study.

7. Improve Learning and Memory Ability
According to the researcher of `Curcumin improves learning and memory ability and its neuroprotective mechanism in mice.`by Pan R, Qiu S, Lu DX, Dong J. (Source from Department of Orthopedics, the First Affiliated Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China.) posted in US National Library of Medicine National Institutes of Health, the result of the study indicated that curcumin significantly improved the memory ability of AD mice in the step-through test, as indicated by the reduced number of step-through errors (P < 0.05) and prolonged step-through latency (P < 0.05). Curcumin also attenuated the neuropathological changes in the hippocampus and inhibited apoptosis accompanied by an increase in Bcl-2 level (P < 0.05), but the activity of Bax did not change (P > 0.05). AlCl(3) significantly reduced the viability of PC12 cells (P < 0.01). Curcumin increased cell viability in the presence of AlCl(3) (P < 0.01). The rate of apoptosis decreased significantly in the curcumin group (P < 0.05) when measured by flow cytometric analysis. Curcumin protected cells by increasing Bcl-2 level (P < 0.05), but the level of Bax did not change (P > 0.05)., researchers conclude thatthis study demonstrates that curcumin improves the memory ability of AD mice and inhibits apoptosis in cultured PC12 cells induced by AlCl(3). Its mechanism may involve enhancing the level of Bcl-2.

8. Gall-bladder function
In a study of `The effect of curcumin and placebo on human gall-bladder function: an ultrasound study.`by Rasyid A, Lelo A. ( from Source Department of Radiology, School of Medicine, Universitas Sumatera Utara, Medan, Indonesia.) posted in posted in US National Library of Medicine National Institutes of Health, researchers found that The fasting gall-bladder volumes of 15.74 +/- 4.29 mL on curcumin and 15.98 +/- 4.08 mL on placebo were similar (P > 0.20). The gall-bladder volume was reduced within the period after curcumin administration. The percentage of gall-bladder volume reduction at 0.5, 1.0, 1.5 and 2.0 h after 20 mg curcumin administration were 11.8 +/- 6.9, 16.8 +/- 7.4, 22.0 +/- 8.5 and 29. 3 +/- 8.3%, respectively, which was statistically significant compared to placebo.

9. Eicosanoidand Blood Platelets
In a study of `Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets.`by Srivastava KC, Bordia A, Verma SK. (Source from Department of Environmental Medicine, Odense University Denmark.) posted in US National Library of Medicine National Institutes of Health, researchers found that this compound inhibited thromboxane B2 (TXB2) production from exogenous [14C] arachidonate in washed platelets with a concomitant increase in the formation of 12-lipoxygenase products. Moreover, curcumin inhibited the incorporation of [14C]AA into platelet phospholipids and inhibited the deacylation of AA-labelled phospholipids (liberation of free AA) on stimulation with calcium ionophore A23187. Curcumin’s anti-inflammatory property may, in part, be explained by its effects on eicosanoid biosynthesis.

10. Cellular Processing
According to the research of `Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.`by Song Y, Sonawane ND, Salinas D, Qian L, Pedemonte N, Galietta LJ, Verkman AS. (Source from Department of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA. Copyright 2004 American Society for Biochemistry and Molecular Biology, Inc.) posted in US National Library of Medicine National Institutes of Health, researchers found that assay of serum curcumin by ethyl acetate extraction followed by liquid chromatography/mass spectrometry indicated a maximum serum concentration of 60 nm, well below that of 5-15 microm, where cellular effects by sarcoplasmic/endoplasmic reticulum calcium pump inhibition are proposed to occur. Our results do not support further evaluation of curcumin for cystic fibrosis therapy.

11. Chemopreventative blocking agents
In a study of Effect of the beta-diketones diferuloylmethane (curcumin) and dibenzoylmethane on rat mammary DNA adducts and tumors induced by 7,12-dimethylbenz[a]anthracene.

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Singletary K, MacDonald C, Iovinelli M, Fisher C, Wallig M. by (Source from Department of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana 61801, USA.)
posted in US National Library of Medicine National Institutes of Health, reseachers found that Female rats provided diets supplemented with dibenzoylmethane at 0.1, 0.5 and 1.0% for 14 days prior to dosing with DMBA exhibited a significant decrease in mammary tumor development, compared with controls. However, tumor development for animals fed diets containing 1.0% curcumin was not different from that of controls. Therefore, dibenzoylmethane, and possibly other structurally-related beta-diketones, warrant examination as breast cancer chemopreventative blocking agents.

12. Lymphomas/Leukemias
In a study of `Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice.`by Huang MT, Lou YR, Xie JG, Ma W, Lu YP, Yen P, Zhu BT, Newmark H, Ho CT. (Source from Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway 08854-8020, USA.) US National Library of Medicine National Institutes of Health, researchers found that the incidence of lymphomas/leukemias was completely inhibited by 1% DBM diet. In contrast, feeding 2% curcumin diet had little or no effect on the incidence of mammary tumors, and the incidence of lymphomas/leukemias was reduced by 53%.

13. Angiogenesis Inhibitor
According to the study of `Curcumin as an inhibitor of angiogenesis.`by Bhandarkar SS, Arbiser JL.(Source from Department of Dermatology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA. ssbhand@emory.edu) posted in PubMed, researchers indicated that Curcumin shows a dose-dependent inhibition on tumor necrosis factor, a versatile cytokine, which has its effect on angiogenesis through the signal transduction pathways, expression of proangiogenic factors, and cell adhesion molecules. Curcumin’s effect on the overall process of angiogenesis compounds its enormous potential as an antiangiogenic drug.

14. Perisinusoidal Cells (Hepatic Stellate Cell (HSC))
In a study of `De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation.`by Zheng S, Yumei F, Chen A. (Source from Department of Pharmacology, Nanjing Medical University, China.) posted in PubMed, researchers found that
De novo synthesis of GSH is a prerequisite for curcumin to inhibit HSC activation. These results provide novel insights into the mechanisms of curcumin as an antifibrogenic candidate in the prevention and treatment of hepatic fibrosis.

15. Liver Disease
According to the study of `Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes.`by Nanji AA, Jokelainen K, Tipoe GL, Rahemtulla A, Thomas P, Dannenberg AJ. (Source from Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-4283, USA. amin.nanji@uphs.upenn.edu) posed in PubMed, researchers found that
Treatment with curcumin prevented both the pathological and biochemical changes induced by alcohol. Because endotoxin and the Kupffer cell are implicated in the pathogenesis of ALD, we investigated whether curcumin suppressed the stimulatory effects of endotoxin in isolated Kupffer cells. Curcumin blocked endotoxin-mediated activation of NF-kappaB and suppressed the expression of cytokines, chemokines, COX-2, and iNOS in Kupffer cells. Thus curcumin prevents experimental ALD, in part by suppressing induction of NF-kappaB-dependent genes.

 For the Sources of the studies, please paste the tittle of the studies for the related links, as the limitation of links in this publcation

For other health and Phytochemical articles, please visit
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I have been studying natural remedies for disease prevention for over 20 years and working as a financial consultant since 1990. Health Researcher and Article Writer. Master in Mathematics and BA in World Literature and Literary criticism
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Benzene Breakdown

This benzene chemical normally comes in a liquid form and is a faint color yellow or no color at all . Benzene is employed during producing processes of products and petrol. It is located from normal process and human activities and it’s found in crude oil, gasper smoke and more. Benzene exposure can cause cancer and it may also be the beginning of other illnesses.

How Does the Poisoning Happen?

if a person works where this chemical, benzene, is used such as a manufacturing plant or anywhere where extreme levels of benzene is present, they’re in danger of poisoning from the benzene exposure. If benzene is breathed in or if it was swallowed causing harm to the body and this can be a threat to a person’s life. Even if the benzene chemical touches the skin, an individual can get poisoning.

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The Effects of Poisoning by Benzene

A person’s health can be impacted by getting exposed to benzene in a number of ways. Often the effects from the benzene chemical are :
fatigue
Weakness
Fast pulse
Confusion
Unconsciousness

Benzene poisoning can lead to death in harsh cases. There’s been much research done that proves if you are exposed to benzene for a long time there’s a likelihood you can develop blood sicknesses such as leukemia and other cancers.

How are you able to Avoid Poisoning from Benzene?

Avoid the benzene chemical altogether. This is the best prevention. Any area with exaggerated levels of benzene should be avoided. This also includes consuming any products containing the chemical. Occasionally, avoiding this benzene chemical is not practicable. In this example, you must wear protection masks. This may limit the exposure.
if you’re exposed to it, you should take cautionary steps like :

Getting clean air
Taking off the contaminated clothing
Use soapy water for the tarnished area
If the exposure was serious, see your physician

How Can Benzene Poisoning be Treated?

Benzene poisoning cannot be cured and the illnesses that develop thanks to it cannot be cured either. Otherwise, there are treatments that are given to patients for short and long-term exposure.

be sure to follow the steps above if you’ve been exposed to benzene. Get rid of your clothing and get them washed thoroughly. You do not wish to take the clothes in your auto or your home before washing. Be sure to clean your hands right away also mmediately after the exposure.

If you suffer with benzene poisoning thanks to the exposure to benzene for a substantial period of time, contact your consultant.
Your doctor will order blood tests to be certain the benzene poisoning aren’t influenced your health .

Benzene poisoning can be life changing but with the right info and taking the essential steps to avoid any exposure. If you or somebody you care about has benzene poisoning, see your consultant immediately. Talk with an attorney also for any legal support.

Benzene Poisoning Examples
I write aboutBenzene Poisoning and it’s effects.
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By contrast, in Germany and the Netherlands there are centers where it is practiced successfully for many years, often in combination with conventional therapies. Hyperthermia is defined as the heat treatment (for about 1 hour) of the tissue up to 42-43 ° C, temperatures at which cancer cells undergo death. To achieve this there are several techniques, but not all work the same way, not all prove to be equally effective. You must select the most suitable technique depending on the type of cancer, never apart from the general conditions of the patient. Side effects are minimal and it is repeatable over time. It is generally suitable for all types of solid tumors(not for cancers of the blood). To achieve the rise in temperature radio frequency electromagnetic fields are used, focused by special antennas.

The frequency used is 13.56 MHz. Besides the direct anti tumor action; hyperthermia is also an important action with adjuvant therapies.More precise radiation therapy in combination with hyperthermia induces a radio sensitizing effect, an increase of efficacy of one and a half to three times the ionizing radiation alone. The interaction with chemotherapy allows greater penetration of cytotoxic drugs inside the cells due to an increase in cell permeability resulting in the raising of the temperature. In essence, enhancing the effects of conventional therapies can decrease the dose of chemotherapy and radiation, thus reducing the heavy side effects. In addition, the increase in body temperature stimulates the immune system through the release of immuno regulatory substances, cytokines, which have a protective effect for the body.

One of the world’s leading experts of hyperthermia, head of hematology and oncology at the University of Pavia reported that heat produces the breaking of the DNA of cancer cells. More precisely, the tumor blood vessels, muscle scaffold-free, do not allow for lack of elasticity, the physiological vasodilatation that allows heat dissipation introduced. In this way, the heat would be trapped in the tumor lesions, causing their death. He says that in 30% of cases the tumor regresses, in another 30% will stop temporarily, and it heals in a 5%. The use of hyperthermia is not indicated only in cases where there is a strong pleural effusion, and in cases where the body of the patient is so debilitated that it does not allow a normal immune response.

if you want to get more news,tips, help on cancer visithttp://cancerremover.com/
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The more we can learn about what causes cancer, the more likely we are to find ways to prevent it. Scientists study patterns of cancer in the population to look for factors that affect the risk of developing this disease. In the laboratory, they explore possible causes of cancer and try to determine what actually happens when normal cells become cancerous.

Our current understanding of the causes of cancer is incomplete, but it is clear that cancer is not caused by an injury, such as a bump or bruise. And although being infected with certain viruses may increase the risk of some types of cancer, cancer is not contagious no one can “catch” cancer from another person.

Cancer develops gradually as a result of a complex mix of factors related to environment, lifestyle, and heredity. Scientists have identified many risk factors that increase the chance of getting cancer. They estimate that about 80 percent of all cancers are related to the use of tobacco products, to what we eat and drink, or, to a lesser extent, to exposure to radiation or cancer-causing agents (carcinogens) in the environment and the workplace. Some people are more sensitive than others to factors that can cause cancer.

Many risk factors can be avoided. Others, such as inherited risk factors, are, unavoidable. It is helpful to be aware of them, but it Is also important to keep in mind that not everyone with a particular risk factor for cancer actually gets the disease; in fact, most do not. People at risk can help protect themselves by avoiding risk factors where possible and by getting regular checkups so that, if cancer develops, it is likely to be found early.

These are some of the factors that are known to increase the risk of cancer.

Tobacco – Tobacco causes cancer. In fact, smoking tobacco, using “smokeless” tobacco, and being regularly exposed to environmental tobacco smoke without smoking are responsible for one-third of all cancer deaths. Smoking accounts for more than 85 percent of all lung cancer deaths. If you smoke, your risk of getting lung cancer is affected by the number and type of cigarettes you smoke and how long you have been smoking. Overall, for those who smoke one pack a day, the chance of setting lung cancer is about 10 times greater than for nonsmokers.

Smokers are also more likely than nonsmokers to develop several other types of cancer (such as oral cancer and cancers of the larynx, esophagus, pancreas, bladder, kidney, and cervix). The risk of cancer begins to decrease when a smoker quits, and the risk continues to decline gradually each year after quitting.

The use of smokeless tobacco (chewing, tobacco and snuff) causes cancer of the mouth and throat. Pre-cancerous conditions, or tissue changes that may lead to cancer, begin to go away after a person stops using smokeless tobacco.

Exposure to environmental tobacco smokes, also called involuntary smoking, increases the risk of lung cancer for nonsmokers. The risk goes up 30 percent or more for a nonsmoking spouse of a person who smokes. Involuntary smoking causes about 4,000 lung cancer deaths in this country each year.

If you use tobacco in any form and you need help quitting, talk with your doctor or dentist, or join a smoking cessation group sponsored by a local hospital or voluntary organization.

Diet : Your choice of foods may affect your chance of developing cancer. Evidence points to a link between a high-fat diet and certain cancers, such as cancer of the breast, colon, uterus, and prostate. Being seriously overweight appears to be linked to increased rates of cancer of the prostate, pancreas, uterus, Colon, and ovary, and to breast cancer in older women. On the other hand, studies suggest that foods containing fiber and certain nutrients help protect us against some types of cancer. You may be able to reduce your cancer risk by making some simple food choices. Try to have a varied, well-balanced diet that includes generous amounts of foods that are high in fiber, vitamins, and minerals. At the same time, try to cut down on fatty foods. You should eat five servings of fruits and vegetables each day, choose more whole-grain breads and cereals, and cut down on eggs, high-fat meat, high-fat dairy products (such as whole milk, butter, and most cheeses), salad dressings, margarine, and cooking oils.

Sunlight : Ultraviolet radiation from the sun and from other sources (such as sunlamps and tanning booths) damages the skin and can cause skin cancer. (Two types of ultraviolet radiation–UVA and UVB–are explained in the Medical Terms section.) Repeated exposure to ultraviolet radiation increases the risk of skin cancer, especially if you have fair skin or freckle easily. The sun is ultraviolet rays are strongest during the summer from about 11 a.m. to about 3 p.m. (daylight saving time). The risk is greatest at this time, when the sun is high overhead and shadows are short. As a rule, it is best to avoid the sun when your shadow is shorter than you are.

Protective clothing, such as a hat and, long sleeves, can help block the sun’s harmful rays. You can also use sunscreens to help protect yourself. Sunscreens are rated in strength according to their SPF (sun protection factor), which ranges from 2 to 30 and higher. Those rated 15 to 30 block most of the sun’s harmful rays.

Alcohol. Drinking, large amount of alcohol increases the risk of cancer of the mouth, throat, esophagus, and larynx. (People who smoke cigarettes and drink alcohol have an especially high risk of getting these cancers.) Alcohol can damage the liver and increase the risk of liver cancer. Some studies suggest that drinking alcohol also increases the risk of breast cancer. So if you drink at all, do so in moderation-not more than one or two drinks a day.

Radiation : X-rays used for diagnosis expose you to very little radiation and the benefits nearly always outweigh the risks. However, repeated exposure can be harmful, so it is a good idea to talk with your doctor or dentist about the need for each x-ray and ask about the use of shields to protect other parts of your body. Before 1950, X-rays were used to treat non-cancerous conditions (such as an enlarged thymus, enlarged tonsils and adenoids, ringworm of the scalp, and acne) in children and young adults. People who have received radiation to the head and neck have a higher-than-average risk of developing thyroid cancer years later. People with a history of such treatments should report it to their doctor and should have a careful exam of the neck every 1 or 2 years.

Also, radiation used in the treatment of some types of cancer can increase the risk of developing a second cancer. Patients having radiation therapy may want to discuss this issue with their doctor.

Chemicals and other substances in the workplace being exposed to substances such as metals, dust chemicals, or pesticides at work can increase the risk of cancer. Asbestos, nickel, cadmium, uranium, radon, vinyl chloride, benzidene, and benzene are well-known examples of carcinogens in the workplace. These may act alone or along with another carcinogen, such as cigarette smoke. For example, inhaling asbestos fibers increases the risk of lung diseases, including cancer, and the cancer risk is especially high for asbestos workers who smoke. It is important to follow work and safety rules to avoid contact with dangerous materials.

Hormone replacement therapy: Many women use estrogen therapy to control the hot flashes, vaginal dryness, and osteoporosis (thinning of the bones) that may occur during menopause. However, studies show that estrogen use increases the risk of cancer of the uterus. Other studies suggest an increased risk of breast cancer among women who have used high doses of estrogen or have used estrogen for a long time. At the same time, taking estrogen may reduce the risk of heart disease and osteoporosis.

The risk of uterine cancer appears to be less when progesterone is used with estrogen than when estrogen is used alone. But some scientists are concerned that the addition of progesterone may also increase the CANCER risk of breast cancer.

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HOMEOPATHY APPCHOCH IN STOMACH

Out of ten person, one person suffering fron gestrities and out of them hundred one person suffering from stoch cancer.If the cancer can be identified at a time when it only involves the superficial lining layer of the stomach and only involves a few cells and such a stomach cancer is surgically removed 90 % of these individuals are likely to have a normal life span . However if the stomach cancer has involved all the layers of the stomach this chance decreases to 50% and if it has spread outside the stomach or to distant organs of the body the chances of surviving in the long term are extremely gloomy .

CAUSE FOR STOMACH CANCER

1. Benign stomach (gastric ) ulcer , in most instances these benign ulcers in the stomach do not become malignant although in a few cancerous change can supervene after many years . Helicobacter pylori infection of the stomach appears to be an important cause of gastric ulcers .

2. Chronic duodenal ulcer , this is a common condition of the duodenum , the organ situated next to the stomach . we can reassure those with this condition that even after many years of having a chronic duodenal ulcer , the chances of it becoming malignant are almost nil.

3. Gastritis with low or absent stomach acid production . This situation can occur in an uncommon illness. Pernicious anemia and it can also occur without any obvious reason . Here absent or low levels of stomach acid which is normally produced to aid digestion is associated with the disappearance of gastric glands and this is called atrophic gastritis . Atrophic gastritis is a pre malignant condition .

GENATIC DISPOSITION OF STOMACH CANCER

Inherited causes :family history of stomach cancer ,such a history in a near relative doubles a person’s chances of developing stomach cancer during their life time

Type A blood group ,the common blood groups are A,B,O ,and AB. A person with type A blood has a 20% increased chance of developing stomach cancer during their life time compared to those with other blood groups

Personal health risks: presence of Helicobacter pylori in the stomach .this is an organism which in recent has been associated not only with stomach cancer but also with gastric and duodenal ulcers and with inflammatory changes called gastritis . why Helicobacter infection is present in some individuals but not in others is at present in some individuals but not in others is at present is uncertain , although it may be linked to both undesirable Helicobacter infection probably cause no symptoms . Helicobacter Pylori infection can usually be eradicated by the use of suitable antibiotics . It has also been suggested recently by Australian scientists that the regular intake of acidophilus bacteria (found in some brands of yoghurt and in some bacteria supplements )can also eradicate Helicobacter infection. Previous surgical removal of part of the stomach (partial gastrectomy ) for a non malignant condition , such as a gastric or duodenal ulcer . This become a stomach cancer risk some 15-40 years after the stomach has been removed . Pernicious anemia ,Individuals with this uncommon condition not only have anemia but also have no normal stomach acid production . They develop the condition previously described , atrophic gastritis . Individuals with atrophic gastritis have a 10 %chance of developing stomach cancer during their life time . Low or absent stomach acid production with atrophic gastritis , even in the absence of pernicious anemia , this is a risk for the future development of stomach cancer

Life style health risks : Dietary factors, a special risk for stomach cancer is a diet which is low in vegetables , fruit and cereals and particularly those fruits , vegetables and cereals which contain a lot of beta-carotene , vitamin-c and vitamin-e

A diet high in pickled . smoked , salted or cured food or foods preserved with nitrate , such as salami ,sausages , hot dogs , smoked meat , smoked fish or pickled food of any kind are also risks for stomach cancer . These dietary factors are probably important because the risk foods described above all seem to produce carcinogens

called nitrosamines . Also vitamin-C acts as antioxidant and has other actions which neutralize the effects of nitrosamines . Dietary factors are probably the most important single cause of stomach cancer . Smoking , a recent Australian study which examined all the scientific evidence published over the years has found that smoking is likely to be an important contributory cause of stomach cancer .

PRIMARY PREVENTION CANCER :

1.Dietary changes it is particularly important to have a high consumption of fruit ,vegetables and cereals which contain beta-carotene ,vitamin-c and vitamin-e and at the same time avoid or eat very little pickled ,smoked ,salted ,cured and nitrate –preserved foods .In a recently reported study from China ,where stomach cancer is still relatively common ,the daily use of vitamin-e ,beta carotene and selenium supplements decreased stomach cancer risk by one-fifth .

2. Avoid smoking ,hints and guidance about quitting smoking are described

3. Eradicate Helicobacter Pylori , if helicobacter infection has been shown to be present ,suitable antibiotics can be used recent research suggests that the acidophilus bacteria found in some dietary supplements may also been effective way to eliminate helicobacter infection

4. Aspirin based mainly on experimental data ,the regular use of aspirin as a preventive for stomach cancer has been advanced . However the human evidence of a preventive role for aspirin in stomach cancer is insufficient at present to make such a recommendation .

ROLE FOR HOMEOPATHY TREATMENT

In alternative medicine in homoeopathy medicine can cure cancer in various age group of person. In early stage of cancer may help to patient life Many people with cancer want to learn all they can about their disease and their treatment choices so they can take an active part in decisions about their medical care. Often, it helps to make a list of questions to ask the doctor. Patients may take notes or, with the doctor’s consent, tape record the discussion. Some patients also find it helps to have a family member or friend with them when they talk with the doctor to take part in the discussion, to take notes, or just to listen.

• Here are some questions may want to ask the doctor: What are the chances that the treatment will be successful?
• Would a clinical trial be appropriate for me?
• What are the risks and possible side effects of each treatment?

Although the side effects of radiation therapy can be unpleasant, the doctor can usually treat or control them. It also helps to know that, in most cases, they are not permanent.
number of white blood cells, cells that help protect the body against infection
Chemotherapy —the side effects of chemotherapy depends mainly on the drugs and doses the patient receives. Generally, anticancer drugs affect cells that divide rapidly. These include blood cells, which fight infection, help the blood to clot, or carry oxygen to all parts of the body. When blood cells are affected by anticancer drugs, patients are more likely to get infections, may bruise or bleed easily, and may have less energy. Cells that line the digestive tract also divide rapidly. As a result of chemotherapy, patients may have side effects, such as loss of appetite, nausea and vomiting, hair loss, or mouth sores. For some patients, the doctor may prescribe medicine to help with side effects, especially with nausea and vomiting. Usually, these side effects gradually go away during the recovery period or after treatment stops. Hair loss another side effect of chemotherapy, is a major concern for many patients. Some chemotherapy drugs only cause the hair to thin out, while others may result in the loss of all body hair. Patients may feel better if they decide how to handle hair loss before starting treatment.

In some men and women, chemotherapy drugs cause changes that may result in a loss of fertility (the ability to have children). Loss of fertility may be temporary or permanent depending on the drugs used and the patient’s age. For men, sperm banking before treatment may be a choice. Women’s menstrual periods may stop, and they may have hot flashes and vaginal dryness. Periods are more likely to return in young women. In some cases, bone marrow transplantation and peripheral stem cell support are used to replace tissue that forms blood cells when that tissue has been destroyed by the effects of chemotherapy or radiation therapy.

Hormone Therapy –Hormone therapy can cause a number of side effects. Patients may have nausea and vomiting, swelling or weight gain, and, in some cases, hot flashes. In women, hormone therapy also may cause interrupted menstrual periods, vaginal dryness, and, sometimes, loss of fertility. Hormone therapy in men may cause impotence, loss of sexual desire, or loss of fertility. These changes may be temporary, long lasting, or permanent.

HOMOEOPATHIC TREATMENT/MEDICINES

CHELIDINIUM : It has also cured cancer of the stomach when in a ,vomiting for cancer of throat , mouth or stomach .

Condurango : In cancer of oesophagus or stomach . There are many other medicines , only few have been mentioned

Dr Harshad Raval MD[hom]
Honorary consultant homeopathy physician to his Excellency governors of Gujarat India. Qualified MD consultant homeopath ,International Homeopathy adviser, books writer and columnist. Specialist in kidney, cancer, psoriasis, leucoderma and other chronic disease,. www.homeopathyonline.in email : info@homeopathyonline.in
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Now we come to the basic question: why BMT? In patients with any of the diseases mentioned above, either a large number of defective or immature blood cells are produced (in the case of leukemia), or there is an exceedingly low blood count (in the case of aplastic anemia). These defective blood cells accumulate in the blood cell and interfere with their function, or even invade other tissues. These abnormal blood cells can be destroyed by large doses of radiation or chemotherapy, which can even destroy normal blood cells in the bone marrow. A bone marrow transplant can be used by the doctors to treat abnormal blood cells with radiation and replace the damaged bone marrow with new one. Even though, BMT does not guarantee against recurrence of the disease, but can help the patient enjoy a healthier life for a prolonged period of time.

A transplant of any sorts is accompanied with several complications and is a harrowing experience to say the least. For a BMT, a patient has to be physically and mentally healthy enough to undergo the rigors of this complicated procedure. A battery of tests is conducted before the transplant and then after it to make sure that the body has not been impaired in any way. Bone marrow transplant is conducted by an expert team of doctors and nurses who specialize in this particular procedure. In this case, doctors also need to provide physical and psychological support to the patient and his family, before, during and even after the bone marrow transplant.

Medical Tourism search engine offering users the ability to compare Surgery Overseas cosmetic and medical procedure costs and reputation from.
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(For information, Antioxidants are protective compounds that protect the body cells against free radicals (reactive oxygen cells) which are produced as daily metabolic process. These free radicals are supposed to play a role in diseases like sclerosis and cancer.)

Test results shows that neem produces an antioxidant compound glutathione which is a carcinogen-detoxifying enzyme. Studies were made by the application of that antioxidant compounds in rats and found that it can cure brain damages by producing an acid called ascorbic acid in brain. Neem parts like bark, leaf and seed oil has oxygen radical absorbance capacity/gram ranging from 350-500 as per data recovered from the laboratory tests. It is also seen that it contains protein that can improve a human immune system. By improving the immune capacity, human cells get defended against cancer cells.  Proteins from neem are extracted by using two compounds sodium chloride and sodium sulphate. Neem has been tested against many cancers and got positive results by the betterment in health of patients. Neem in the form of cream is used for the treatment of skin cancer. Internal application of those creams can also treat lymphocytic cancer. Neem Oil comprises of compounds polysaccharides and liminoids which can also treat tumor. It is found successful against lymphocytic leukemia too. Extracts of neem prevents the spread of cancer cells to other parts of the body making it confined and slowly diminishes it.

Products containing neem are preferred for use either it may be a personal care product or health care product because cancer causing chemicals are available in the products which we are using in our routine life. Products with neem at very less dosage can also be taken but strictly with a prescription. Sole Neem products need not require any health advisor.

Unique properties of Neem thus pave a way of hope and solution for the cancer patients as we all know that cancer is considered one of the world’s dreadful disease which is less curative when identified at mature stage. Hope this natural gift will make a ray of confidence at that stage too.

Adam teaser is fond of writing articles in Bio Science, He has got 10 years of experience in Bio research and he recommends to buy Neem Oil from Plasma Power , which is EPA registered Neem oil registered for sale in Florida, Texas, California, Alabama, Mississippi, Louisiana, Hawaii, New Mexico, Minnesota, Michigan and Iowa.
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First, let’s look at what they are. Pluripotent stem cells are found in relatively small numbers in the body in various tissues and umbilical cord blood. Much of the research has been to identify their differentiation potential and we have even seen procedures whereby umbilical cord stem cells have been re-injected into patients. They do not attract the same controversy surrounding embryonic stem cells, and because they are derived from a born human being, are also classified as adult stem cells.

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Next, let’s look at what they do. For most pluripotent adult stem cells, their ability to regenerate is limited to the tissues they are taken from. For example, stem cells taken from the skin will only become skin cells. Injecting them into the liver, will not result in new liver cells. Researchers are trying to find a way to change these pluripotent adult stem cells to become any cell of the body.

Finally, let’s look at why pluripotent stem cells are not the answer to all our health issues. As we have already seen, PSC taken from skin for example, cannot become new cells of the liver. This won’t help people with cardiovascular disease or degenerative conditions such as Parkinson’s. The answer lies in another type of adult stem cells — the ones from our bone marrow.

For years, we’ve used these successfully to treat leukemia and blood/bone cancers by transplanting them into patients. The newest research however, indicates there are some 150 million adult stem cells in our bone marrow and that as stem cells that can become any type of tissue, they represent the renewal system of the body.

So there you have it, everything you wanted to know about pluripotent stem cells. We’ve looked at what they, what they do and finally why they are not the answer to our health problems. All the latest research points to adult stem cells from our own bone marrow being the natural renewal system of our bodies, so all we need to do is get more of them to release into our bloodstream.

Learn How to Unleash the Awesome Power of Your Own Stem Cells with our Stem Cell Enhancer products.
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Anyone using this herb for anti-aging purposed should also take food based multi-vitamins and change their diet to organic foods when available. There also needs to be a yoga or exercise program included to help balance neurotransmitters and hormones. A well planned detoxification program followed up with bio-identical hormones is also needed.

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Astragulus has antibiotic properties. It is an antiviral and encourages the body systems to function correctly. It has diuretic properties. It increases blood circulation. There are many types of blood diseases which may benefit from this illness. Astragulus increases sperm motility. It lowers blood glucose. It lowers blood pressure and enhances cardiac function in many ways. It is an anti-inflammatory herb. Astragulus protects the liver and kidneys. It may be throughout this action that Astragulus helps prevent senility.

Astragulus can be uses to treat Alzheimer’s disease. Astragulus can improve brain issues connected with Chronic Fatigue like brain fog. Astragulus can improve learning and increase memory. It may help patients with diabetes insipidus. This is a type of brain disease due to impaired pituitary function. If the pituitary gland is impaired due to inflammation or viral attack, this herb could reverse the condition. Multiple sclerosis can be improved for many people using this herb due to its antiviral activity and its ability to enhance the immune system.

There are very few herbs that are able to treat eating disorders like anorexia and this herb is the best single herb to handle anorexia. Another brain illness that can treated with astragulus is dementia and impaired cognitive function. Physical debilitation and brain injury similar to those found in car accidents can be improved for many with this herb taken for about two months. Do not take this herb without informing your healthcare professional.

© 2010 by Dr R Stone, MD - Alternative Medicine, India

Dr R Stone has a Medical Degree in Alternative Medicine from India, MBA in Finance from the University of St. Thomas in Houston, and BBA from the University of Texas at Austin. Dr R Stone also trained in Laser Therapy and NAET. Dr R Stone has trained with the International Association of Acupuncture and Electro-Therapeutics. Dr Stone owns Medici Galleries, an online fine arts gallery. Dr Stone volunteers with the Austin Art Alliance and Austin Film Festival.Honors: Cambridge Who’s Who and Stanford Who’s WhoMemberships: World Academy of Anti-Aging Medicine, American Academy of Anti-Aging Medicine, Kunsthaus Museum (Zurich), Austin Modern Art Museum, New York Metropolitan Museum of Art, Dali Foundation, and Chagall FoundationVisit Dr R Stone online at  ErectileDysfunctionPlace.com and www.AphrodisiacRX.com 
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